Which of the following statements is true concerning secondary active transporters?

The concept of secondary active transport involves the movement of substances across a membrane against their concentration gradient, using the energy derived from the movement of another substance down its concentration gradient. Electrogenic carriers, by definition, are those that transport ions in such a way that they generate an imbalance of charge across the membrane. This occurs because these carriers typically move charged particles (such as ions) in a way that results in a net transfer of charge, creating a difference in electric potential.

In the context of secondary active transport, if a carrier moves more positive charges out of the cell than it moves in, it will create a positive charge outside and a negative charge inside, thus generating an electrical gradient. This charge difference is critical for various physiological processes, including the electrical activity of neurons and muscle cells. Therefore, the statement indicating that electrogenic carriers generate a charge difference across the membrane accurately reflects their role in maintaining and modifying electrochemical gradients essential for cell function.